Products
FAS/CD95 antibody
- Product Name
- FAS/CD95 antibody
- Catalogue No.
- FNab03017
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 4B6
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- Fas(TNF receptor superfamily, member 6)
- Alternative Names
- ALPS1A antibody, APO 1 antibody, Apo 1 antigen antibody, APT1 antibody, CD95 antibody, FAS antibody, FAS1 antibody, FASLG receptor antibody, FASTM antibody, TNFRSF6 antibody
- UniProt ID
- P25445
- Observed MW
- 38-45 kDa
Application
- Tested Applications
- ELISA, WB, FC,IHC
- Recommended dilution
- WB: 1:1000-1:8000; IHC: 1:50-1:500
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab03017(FAS/CD95 antibody) at dilution of 1:4000
Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab03017(FAS/CD95 antibody) at dilution of 1:200.
- Background
- Fas(CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor(TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex(DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The molecular mass of native Fas is 38 kDa, the high molecular weight form(40-55 kDa) of Fas is due to glycosylation.
